Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin

Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin

ERK activation is enhanced by the scaffolding proteins KSR and MP1, localized near the cell membrane and late endosomes respectively, but little is known about their dynamic interplay. We develop here a mathematical model with ordinary differential equations to describe the dynamic activation of EGF...

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Main Authors: Huang, Lu (Contributor), Pan, Catherine Qiurong (Author), Li, Baowen (Author), Tucker-Kellogg, Lisa (Contributor), Tidor, Bruce (Contributor), Chen, Yu Zong (Contributor), Low, Boon Chuan (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Singapore-MIT Alliance in Research and Technology (SMART) (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2011-11-10T14:54:21Z.
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