Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8⁺ T cells

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8⁺ T cells

Variable sensitivity to T-cell-receptor (TCR)- and IL-7-receptor (IL-7R)-mediated homeostatic signals among naïve T cells has thus far been largely attributed to differences in TCR specificity. We show here that even when withdrawn from self-peptide-induced TCR stimulation, CD8+ T cells exhibit het...

Full description

Bibliographic Details
Main Authors: Palmer, Megan Joan (Contributor), Mahajan, Vinay S. (Contributor), Chen, Jianzhu (Contributor), Irvine, Darrell J (Author), Lauffenburger, Douglas A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Lauffenburger, Douglas A. (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-01-04T20:06:26Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items