A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

Tunicamycin (TM) inhibits eukaryotic asparagine-linked glycosylation, protein palmitoylation, ganglioside production, proteoglycan synthesis, 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity, and cell wall biosynthesis in bacteria. Treatment of cells with TM elicits endoplasmic reticulum str...

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Bibliographic Details
Main Authors: Reiling, Jan H. (Contributor), Clish, Clary (Contributor), Carette, Jan E. (Contributor), Varadarajan, Malini (Contributor), Brummelkamp, Thijn R. (Contributor), Sabatini, David (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences (PNAS), 2012-02-01T20:47:46Z.
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