Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity

Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity

The HDL receptor, scavenger receptor, class B, type I (SR-BI), is a homooligomeric cell surface glycoprotein that controls HDL structure and metabolism by mediating the cellular selective uptake of lipids, mainly cholesteryl esters, from HDL. The mechanism underlying SR-BI-mediated lipid transfer, w...

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Main Authors: Saenz-Vash, Veronica (Author), Romer, Katherine A. (Contributor), Xu, Shangzhe (Contributor), Yesilaltay, Ayce (Contributor), Krieger, Monty (Contributor), Yu, Miao (Author), Nieland, Thomas J (Author), Penman, Marsha L (Author), Carr, Steven A (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Yua, Miao (Contributor), Nieland, Thomas J. (Contributor), Penman, Marsha L. (Contributor), Carr, Steven A. (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences (PNAS), 2012-02-01T21:24:15Z.
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