Coordinate linkage of HIV evolution reveals regions of immunological vulnerability
Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations o...
Main Authors: | , , , , , , , , , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
Proceedings of the National Academy of Sciences (PNAS),
2012-02-01T22:14:44Z.
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Subjects: | |
Online Access: | Get fulltext |