Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

Whereas the roles of proangiogenic factors in carcinogenesis are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elaborated. We investigated the roles of three EAIs during de novo tumorigenesis to further test the angiogenic balance hypothesis, which suggests...

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Main Authors: Xie, Liang (Author), Duncan, Michael B. (Author), Pahler, Jessica (Author), Sugimoto, Hikaru (Author), Martino, Margot (Author), Lively, Julie (Author), Mundel, Thomas (Author), Soubasakos, Mary (Author), Takeda, Takaaki (Author), Inoue, Masahiro (Author), Lawler, Jack (Author), Hanahan, Douglas (Author), Rubin, Kristofer (Contributor), Kalluri, Raghu (Contributor), Hynes, Richard O (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hynes, Richard O. (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences (PNAS), 2012-02-03T17:21:37Z.
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