A Novel Role of the WNT-Dishevelled-GSK3β Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

A Novel Role of the WNT-Dishevelled-GSK3β Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

Based on earlier gene expression and chromatin array data, we identified the protein, dishevelled (DVL)-2, as being regulated in the nucleus accumbens (NAc), a key brain reward region, in the mouse social defeat model of depression. Here, we validate these findings by showing that DVL2 mRNA and prot...

Full description

Bibliographic Details
Main Authors: Wilkinson, Matthew B. (Author), Dias, Caroline (Author), Magida, Jane (Author), Mazei-Robison, Michelle S. (Author), Lobo, Mary Kay (Author), Kennedy, Pamela J. (Author), Dietz, David M. (Author), Covington III, Herbert E. (Author), Russo, Scott (Author), Ghose, Subroto (Author), Tamminga, Carol (Author), Nestler, Eric J. (Author), Neve, Rachael L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2012-02-08T21:17:49Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items