Effect of D222G Mutation in the Hemagglutinin Protein on Receptor Binding, Pathogenesis and Transmissibility of the 2009 Pandemic H1N1 Influenza Virus

Effect of D222G Mutation in the Hemagglutinin Protein on Receptor Binding, Pathogenesis and Transmissibility of the 2009 Pandemic H1N1 Influenza Virus

Influenza viruses isolated during the 2009 H1N1 pandemic generally lack known molecular determinants of virulence associated with previous pandemic and highly pathogenic avian influenza viruses. The frequency of the amino acid substitution D222G in the hemagglutinin (HA) of 2009 H1N1 viruses isolate...

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Main Authors: Belser, Jessica A. (Author), Pappas, Claudia (Author), Zeng, Hui (Author), Cox, Nancy J. (Author), Katz, Jacqueline M. (Author), Tumpey, Terrence M. (Author), Jayaraman, Akila (Contributor), Raman, Rahul (Contributor), Sasisekharan, Ram (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Singapore-MIT Alliance in Research and Technology (SMART) (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2012-02-10T17:15:53Z.
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