Conserved Regulation of p53 Network Dosage by MicroRNA-125b Occurs through Evolving miRNA-Target Gene Pairs

Conserved Regulation of p53 Network Dosage by MicroRNA-125b Occurs through Evolving miRNA-Target Gene Pairs

MicroRNAs regulate networks of genes to orchestrate cellular functions. MiR-125b, the vertebrate homologue of the Caenorhabditis elegans microRNA lin-4, has been implicated in the regulation of neural and hematopoietic stem cell homeostasis, analogous to how lin-4 regulates stem cells in C. elegans....

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Main Authors: Le, Minh T. N. (Author), Shyh-Chang, Ng (Author), Khaw, Swea Ling (Author), Chin, Lingzi (Author), Teh, Cathleen (Author), Tay, Junliang (Author), O'Day, Elizabeth M. (Author), Korzh, Vladimir (Author), Yang, Henry (Author), Lal, Ashish (Author), Lieberman, Judy (Author), Lim, Bing (Author), Lodish, Harvey F (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lodish, Harvey F. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2012-02-10T19:38:54Z.
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