A general screening strategy for peptide-based fluorogenic ligands
A systematic and general approach for identifying efficient probes for class I PDZ domains based on environment-sensitive chromophores is presented. A series of peptides derived from the C-terminal sequence of Stargazin was first used with PDZ domains of PSD-95 and Shank3 to identify the optimal pos...
Main Authors: | Sainlos, Matthieu (Contributor), Iskenderian, Wendy S. (Contributor), Imperiali, Barbara (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Chemical Society,
2012-03-26T14:54:31Z.
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Subjects: | |
Online Access: | Get fulltext |
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