Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Analogous to an assembly line, we employed a modular design for the high-throughput study of 1,536 structurally distinct nanoparticles with cationic cores and variable shells. This enabled elucidation of complexation, internalization, and delivery trends that could only be learned through evaluation...

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Main Authors: Whitehead, Kathryn Ann (Contributor), Nuhn, Lutz (Contributor), Sahay, Gaurav (Contributor), Cheng, Hao (Contributor), Jiang, Shan (Contributor), Ma, Minglin (Contributor), Lytton-Jean, Abigail K. R. (Contributor), Vegas, Arturo (Contributor), Fenton, Patrick (Contributor), Levins, Christopher G. (Contributor), Lee, Haeshin (Contributor), Cortez, Christina (Contributor), Collins, Sean P. (Contributor), Li, Ying Fei (Contributor), Jang, Janice (Contributor), Querbes, William (Author), Zurenko, Christopher (Author), Novobrantseva, Tatiana I. (Author), Love, Kevin T (Author), Langer, Robert S (Author), Anderson, Daniel Griffith (Author), Siegwart, Daniel J. (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Anderson, Daniel G. (Contributor), Siegwart, Daniel (Contributor), Love, Kevin T. (Contributor), Langer, Robert (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2012-04-19T19:23:38Z.
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