Cataract-Causing Defect of a Mutant γ-Crystallin Proceeds through an Aggregation Pathway Which Bypasses Recognition by the α-Crystallin Chaperone
Background: The transparency of the eye lens depends upon maintenance of the native state of the γ- and β-crystallins, which is aided by the abundant chaperones αA- and αB-crystallin. Mature onset cataract, the leading cause of blindness worldwide, involves the polymerization of covalently damaged o...
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science,
2012-07-23T14:47:14Z.
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| Subjects: | |
| Online Access: | Get fulltext |