Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

The molecular mechanisms that drive mucosal T helper type 2 (T[subscript H]2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury c...

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Main Authors: Wills-Karp, Marsha (Author), Rani, Reena (Author), Dienger, Krista (Author), Lewkowich, Ian (Author), Fox, James G. (Contributor), Perkins, Charles (Author), Lewis, Lauren (Author), Finkelman, Fred D. (Author), Smith, Dirk E. (Author), Bryce, Paul J. (Author), Kurt-Jones, Evelyn A. (Author), Wang, Timothy C. (Author), Sivaprasad, Umasundari (Author), Hershey, Gurjit K. (Author), Herbert, De'Broski R. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, The, 2012-07-23T15:50:29Z.
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Online Access:Get fulltext
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100 1 0 |a Wills-Karp, Marsha  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Biological Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Division of Comparative Medicine  |e contributor 
100 1 0 |a Fox, James G.  |e contributor 
100 1 0 |a Fox, James G.  |e contributor 
700 1 0 |a Rani, Reena  |e author 
700 1 0 |a Dienger, Krista  |e author 
700 1 0 |a Lewkowich, Ian  |e author 
700 1 0 |a Fox, James G.  |e author 
700 1 0 |a Perkins, Charles  |e author 
700 1 0 |a Lewis, Lauren  |e author 
700 1 0 |a Finkelman, Fred D.  |e author 
700 1 0 |a Smith, Dirk E.  |e author 
700 1 0 |a Bryce, Paul J.  |e author 
700 1 0 |a Bryce, Paul J.  |e author 
700 1 0 |a Kurt-Jones, Evelyn A.  |e author 
700 1 0 |a Wang, Timothy C.  |e author 
700 1 0 |a Sivaprasad, Umasundari  |e author 
700 1 0 |a Hershey, Gurjit K.  |e author 
700 1 0 |a Herbert, De'Broski R.  |e author 
245 0 0 |a Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection 
260 |b Rockefeller University Press, The,   |c 2012-07-23T15:50:29Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/71751 
520 |a The molecular mechanisms that drive mucosal T helper type 2 (T[subscript H]2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. TFF2 is also necessary for the rapid production of IL-33, a T[subscript H]2-promoting cytokine, by lung epithelia, alveolar macrophages, and inflammatory dendritic cells in infected mice. TFF2 also increases the severity of allergic lung disease caused by house dust mite antigens or IL-13. Moreover, TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T[subscript H]2 responses. 
546 |a en_US 
655 7 |a Article 
773 |t Journal of Experimental Medicine