2'-O Methylation of Internal Adenosine by Flavivirus NS[subscript 5] Methyltransferase

2'-O Methylation of Internal Adenosine by Flavivirus NS[subscript 5] Methyltransferase

RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m[superscript 7]GpppAm) of viral RNA genome. Here we reported, for the first time...

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Main Authors: Dong, Hongping (Author), Chang, David C. (Author), Ho, Chia-Hua (Author), Lim, Siew Pheng (Author), Chionh, Yok Hian (Author), Hia, Fabian (Author), Lee, Yie Hou (Author), Kukkaro, Petra (Author), Lok, Shee-Mei (Author), Dedon, Peter C. (Contributor), Shi, Pei-Yong (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2012-07-23T17:27:55Z.
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