Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase

Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase

Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that allosteric regulation of RNR activity is vital for cell health, the molecular basis of this regulation has been enigmatic,...

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Main Authors: Ando, Nozomi (Author), Brignole, Edward J. (Author), Zimanyi, Christina M. (Author), Funk, Michael Andrew (Author), Yokoyama, Kenichi (Author), Asturias, Francisco J. (Author), Stubbe, JoAnne (Contributor), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences of the United States of America, 2012-07-26T18:04:30Z.
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