Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase
Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that allosteric regulation of RNR activity is vital for cell health, the molecular basis of this regulation has been enigmatic,...
Main Authors: | Ando, Nozomi (Author), Brignole, Edward J. (Author), Zimanyi, Christina M. (Author), Funk, Michael Andrew (Author), Yokoyama, Kenichi (Author), Asturias, Francisco J. (Author), Stubbe, JoAnne (Contributor), Drennan, Catherine L (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Drennan, Catherine L. (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences of the United States of America,
2012-07-26T18:04:30Z.
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Subjects: | |
Online Access: | Get fulltext |
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