Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus

Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus

Effects of the commercial drug zanamivir (Relenza™) covalently attached to poly-l-glutamine on the infectivity of influenza A viruses are examined using the plaque reduction assay and binding affinity to viral neuraminidase (NA). These multivalent drug conjugates exhibit (i) up to a 20,000-fold impr...

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Bibliographic Details
Main Authors: Weight, Alisha Kessel (Contributor), Haldar, Jayanta (Contributor), Cienfuegos, Luis Álvarez de (Contributor), Gubareva, Larisa V. (Author), Tumpey, Terrence M. (Author), Chen, Jianzhu (Contributor), Klibanov, Alexander M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell (John Wiley & Sons), 2012-08-01T18:26:55Z.
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