Enantioselective Synthesis of Axially Chiral Biaryls by the Pd- Catalyzed Suzuki-Miyaura Reaction: Substrate Scope and Quantum Mechanical Investigations
We report efficient syntheses of axially chiral biaryl amides in yields ranging from 80−92%, and with enantioselectivity in the range 88−94% ee employing an asymmetric Suzuki−Miyaura process with Pd(OAc)[subscript 2] and KenPhos as ligand. These studies demonstrate that electron-rich and electron-de...
| Main Authors: | , , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2012-08-01T19:43:20Z.
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| Subjects: | |
| Online Access: | Get fulltext |