Exocyclic Carbons Adjacent to the N[superscript 6] of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB

Exocyclic Carbons Adjacent to the N[superscript 6] of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB

The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidation can be the alkyl carbon adjacent to N1. Such ma...

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Bibliographic Details
Main Authors: Li, Deyu (Contributor), Delaney, James C. (Contributor), Page, Charlotte M. (Contributor), Yang, Xuedong (Contributor), Chen, Alvin S. (Contributor), Wong, Cintyu (Contributor), Essigmann, John M. (Contributor), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2012-08-03T14:58:50Z.
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