Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin
We report the observation of liquid-liquid phase separation in a solution of human monoclonal antibody, IgG2, and the effects of human serum albumin, a major blood protein, on this phase separation. We find a significant reduction of phase separation temperature in the presence of albumin, and a pre...
| Main Authors: | , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences,
2012-08-14T13:01:00Z.
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| Subjects: | |
| Online Access: | Get fulltext |