Polypeptide translocation by the AAA+ ClpXP protease machine

Polypeptide translocation by the AAA+ ClpXP protease machine

In the AAA+ ClpXP protease, ClpX uses repeated cycles of ATP hydrolysis to pull native proteins apart and to translocate the denatured polypeptide into ClpP for degradation. Here, we probe polypeptide features important for translocation. ClpXP degrades diverse synthetic peptide substrates despite m...

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Bibliographic Details
Main Authors: Barkow, Sarah R. (Contributor), Levchenko, Igor (Contributor), Baker, Tania (Contributor), Sauer, Robert T (Author)
Other Authors: move to dc.description.sponsorship (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Sauer, Robert T. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2012-08-28T19:49:58Z.
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