Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity

Biopharmaceuticals represent the fastest growing sector of the global pharmaceutical industry. Cost-efficient production of these biologic drugs requires a robust host organism for generating high titers of protein during fermentation. Understanding key cellular processes that limit protein producti...

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Bibliographic Details
Main Authors: Politano, Timothy James (Contributor), Panagiotou, Vasiliki (Contributor), Stadheim, Terrance A. (Author), Love, Kerry R. (Author), Jiang, Bo, S.M. Massachusetts Institute of Technology (Author), Love, John C (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Love, John C. (Contributor), Love, Kerry Routenberg (Contributor), Love, J. Christopher (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2012-08-29T14:42:36Z.
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