Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement

Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement

Activation of dopamine receptors in forebrain regions, for minutes or longer, is known to be sufficient for positive reinforcement of stimuli and actions. However, the firing rate of dopamine neurons is increased for only about 200 milliseconds following natural reward events that are better than ex...

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Main Authors: Kim, Kyung Man (Author), Baratta, Michael V. (Contributor), Yang, Aimei (Contributor), Lee, Doheon (Author), Fiorillo, Christopher D. (Author), Boyden, Edward (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Media Laboratory (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Program in Media Arts and Sciences (Massachusetts Institute of Technology) (Contributor), Boyden, Edward Stuart (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2012-08-29T16:03:04Z.
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