Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

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Synthetic biology efforts have largely focused on small engineered gene networks, yet understanding how to integrate multiple synthetic modules and interface them with endogenous pathways remains a challenge. Here we present the design, system integration, and analysis of several large scale synthet...

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Bibliographic Details
Main Authors: Miller, Miles Aaron (Contributor), Hafner, Marc (Contributor), Sontag, Eduardo (Author), Davidsohn, Noah Justin (Contributor), Subramanian, Sairam (Author), Purnick, Priscilla E. M. (Author), Lauffenburger, Douglas A. (Contributor), Weiss, Ron (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2012-08-29T17:20:26Z.
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