SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones

SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones

α-Synuclein is a key molecule in the pathogenesis of synucleinopathy including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Sirtuins are NAD[superscript +]-dependent protein deacetylases that are highly conserved and counter aging in lower organisms. We show that...

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Main Authors: Donmez Yalcin, Gizem (Contributor), Arun, Anirudh (Contributor), Chung, Chee Yeun (Author), McLean, Pamela J. (Author), Lindquist, Susan (Contributor), Guarente, Leonard Pershing (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2012-09-05T16:16:34Z.
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