Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation, and reactive oxygen species (ROS) scavenging in skeletal muscle and other tissues, and these processes are thought to be cri...

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Main Authors: Finley, Lydia W. S. (Author), Lee, Jaewon (Author), Souza, Amanda (Contributor), Desquiret-Dumas, Valérie (Author), Bullock, Kevin (Author), Rowe, Glenn C. (Author), Procaccio, Vincent (Author), Clish, Clary (Contributor), Arany, Zoltan (Author), Haigis, Marcia C. (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2012-09-05T18:10:45Z.
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