Bifunctional Polymeric Inhibitors of Human Influenza A Viruses

Bifunctional Polymeric Inhibitors of Human Influenza A Viruses

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Purpose: New antiviral agents were prepared by attaching derivatives of sialic acid (1) and of the drug zanamivir (2) to poly(isobutylene-alt-maleic anhydride) (poly-(1 + 2)) or by mixing poly-1 and poly-2, followed by assaying them against wild-type and drug-resistant influenza A Wuhan viruses. Met...

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Main Authors: Haldar, Jayanta (Author), Alvarez de Cienfuegos, Luis (Contributor), Tumpey, Terrence M. (Author), Gubareva, Larisa V. (Author), Chen, Jianzhu (Contributor), Klibanov, Alexander M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science + Business Media B.V., 2012-09-20T19:24:03Z.
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