Bifunctional Polymeric Inhibitors of Human Influenza A Viruses
Purpose: New antiviral agents were prepared by attaching derivatives of sialic acid (1) and of the drug zanamivir (2) to poly(isobutylene-alt-maleic anhydride) (poly-(1 + 2)) or by mixing poly-1 and poly-2, followed by assaying them against wild-type and drug-resistant influenza A Wuhan viruses. Met...
Main Authors: | Haldar, Jayanta (Author), Alvarez de Cienfuegos, Luis (Contributor), Tumpey, Terrence M. (Author), Gubareva, Larisa V. (Author), Chen, Jianzhu (Contributor), Klibanov, Alexander M. (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
Springer Science + Business Media B.V.,
2012-09-20T19:24:03Z.
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Subjects: | |
Online Access: | Get fulltext |
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