Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network

Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network

Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells (ESCs), and normal kidney. Wilms tumors prominently exhibit large active chromatin d...

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Bibliographic Details
Main Authors: Aiden, Aviva Presser (Author), Rivera, Miguel N. (Author), Rheinbay, Esther (Author), Ku, Manching (Author), Coffman, Erik J. (Author), Truong, Thanh T. (Author), Vargas, Sara O. (Author), Haber, Daniel A. (Author), Bernstein, Bradley E. (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2012-10-15T20:13:39Z.
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