Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling

The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls cell growth in response to nutrient availability and growth factors. TORC1 signaling is hyperactive in cancer, and regulators of TORC1 signaling may represent therapeutic targets for human diseases. To identify novel regulat...

Full description

Bibliographic Details
Main Authors: Lindquist, Robert A. (Contributor), Ottina, Kathleen (Contributor), Wheeler, Douglas B. (Contributor), Hsu, Peggy P. (Contributor), Thoreen, Carson C. (Contributor), Guertin, David A. (Contributor), Ali, Siraj M. (Contributor), Sengupta, Shomit (Contributor), Shaul, Yoav D. (Contributor), Lamprecht, Michael R. (Contributor), Madden, Katherine L. (Author), Papallo, Adam R. (Contributor), Jones, Thouis R. (Contributor), Sabatini, David M. (Contributor), Carpenter, Anne E. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2012-11-01T16:36:53Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items