Rapamycin inhibits mTORC1, but not completely
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
| Main Authors: | , |
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| Other Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Landes Bioscience,
2012-11-01T17:11:51Z.
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| Subjects: | |
| Online Access: | Get fulltext |