Rapamycin inhibits mTORC1, but not completely
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
Main Authors: | Thoreen, Carson C (Author), Sabatini, David (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Thoreen, Carson C. (Contributor), Sabatini, David M. (Contributor) |
Format: | Article |
Language: | English |
Published: |
Landes Bioscience,
2012-11-01T17:11:51Z.
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Subjects: | |
Online Access: | Get fulltext |
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