Structure of the human mTOR Complex I and its implications for rapamycin inhibition

Structure of the human mTOR Complex I and its implications for rapamycin inhibition

The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth in response to the nutrient and energy status of the cell, and its deregulation is common in human cancers. Little is known about the overall architecture and subunit organization of this essential signaling complex. We have...

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Bibliographic Details
Main Authors: Yip, Calvin K. (Author), Murata, Kazuyoshi (Author), Walz, Thomas (Author), Kang, Seong A. (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2012-11-01T17:21:37Z.
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