Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer
The mTOR mediated PI3K/AKT/mTOR signal transduction pathway has been demonstrated to play a key role in a broad spectrum of cancers. Starting from the mTOR selective inhibitor 1 (Torin1), a focused medicinal chemistry effort led to the discovery of an improved mTOR inhibitor 3 (Torin2), which posses...
Main Authors: | , , , , , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS),
2012-11-01T17:44:56Z.
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Subjects: | |
Online Access: | Get fulltext |