Promiscuous binding of extracellular peptides to cell surface class I MHC protein

Promiscuous binding of extracellular peptides to cell surface class I MHC protein

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Algorithms derived from measurements of short-peptide (8-10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K[superscript b], can bind well over 1 million different peptides with significant affinity (<500 nM), a level of ligand-binding prom...

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Bibliographic Details
Main Authors: Eisen, Herman N. (Contributor), Hou, Xun Helen (Contributor), Shen, Chase (Contributor), Wang, Kaidi (Contributor), Tanguturi, Varsha Keelara (Contributor), Smith, Crysela (Contributor), Kozyrytska, Katerina (Contributor), Nambiar, Lakshmi (Contributor), McKinley, Carol A. (Contributor), Chen, Jianzhu (Contributor), Cohen, Richard J. (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2012-11-07T20:11:00Z.
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