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74649 |
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|a McHugh, Thomas J.
|e author
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|a Massachusetts Institute of Technology. Department of Biology
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|a Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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|a Picower Institute for Learning and Memory
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|a RIKEN-MIT Center for Neural Circuit Genetics
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|a Tonegawa, Susumu
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|a McHugh, Thomas J.
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|a Tonegawa, Susumu
|e author
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|a CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation
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|b Wiley Blackwell,
|c 2012-11-15T17:45:15Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/74649
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|a The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols that incorporate time-dependent components, we found that the loss of plasticity at recurrent CA3 synapses resulted in a deficits in contextual conditioning specifically when the exposure to the context was brief or when the unconditioned stimulus was signaled with a competing, predictive unimodal stimulus. Our results suggest CA3 contributes both speed and salience to contextual processing and support the theory of competition between multimodal and unimodal conditioned stimuli for associative learning.
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|a en_US
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|a Article
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|t Hippocampus
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