Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells

Under the instruction of cell-fate-determining, DNA-binding transcription factors, chromatin-modifying enzymes mediate and maintain cell states throughout development in multicellular organisms. Currently, small molecules modulating the activity of several classes of chromatin-modifying enzymes are...

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Main Authors: Kubicek, Stefan (Contributor), Gilbert, Joshua C. (Author), Fomina-Yadlin, Dina (Contributor), Gitlin, Alexander D. (Author), Yuan, Yuan (Contributor), Wagner, Florence F. (Author), Holson, Edward B. (Author), Luo, Tuoping (Author), Lewis, Timothy A. (Author), Taylor, Bradley (Author), Gupta, Supriya (Author), Shamji, Alykhan F. (Author), Wagner, Bridget K. (Author), Clemons, Paul A. (Author), Schreiber, Stuart L. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2012-11-15T20:17:26Z.
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