Mena binds α5 integrin directly and modulates α5β1 function

Mena binds α5 integrin directly and modulates α5β1 function

Mena is an Ena/VASP family actin regulator with roles in cell migration, chemotaxis, cell-cell adhesion, tumor cell invasion, and metastasis. Although enriched in focal adhesions, Mena has no established function within these structures. We find that Mena forms an adhesion-regulated complex with α5β...

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Main Authors: Gupton, Stephanie L. (Contributor), Riquelme, Daisy Noelia (Contributor), Hughes-Alford, Shannon Kay (Contributor), Tadros, Jenny (Contributor), Rudina, Shireen S. (Contributor), Hynes, Richard O. (Contributor), Lauffenburger, Douglas A. (Contributor), Gertler, Frank (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, The, 2012-11-19T17:23:21Z.
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