Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

Following DNA damage, cells display complex multi-pathway signaling dynamics that connect cell-cycle arrest and DNA repair in G1, S, or G2/M phase with phenotypic fate decisions made between survival, cell-cycle re-entry and proliferation, permanent cell-cycle arrest, or cell death. How these phenot...

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Bibliographic Details
Main Authors: Tentner, Andrea R. (Author), Lee, Michael J. (Author), Ostheimer, Gerard (Contributor), Samson, Leona D. (Contributor), Lauffenburger, Douglas A. (Contributor), Yaffe, Michael B. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Tentner, Andrea R (Contributor), Lee, Michael (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-11-19T18:29:28Z.
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