Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

We obtained unanticipated synthetic byproducts from alkylation of the δ[superscript 1] nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest-affinity byproduct, bearing a C[subscript 6]H[subscript 5](CH[subscript...

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Main Authors: Liu, Fa (Author), Park, Jung-Eun (Author), Qian, Wen-Jian (Author), Gräber, Martin (Author), Berg, Thorsten (Author), Lee, Kyung S. (Author), Lim, Daniel Cham-Chin (Author), Yaffe, Michael B (Author), Burke, Terrence R. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Lim, Dan (Contributor), Yaffe, Michael B. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-11-28T18:01:30Z.
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