17(lowercase beta)-estradiol and Tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice

17(lowercase beta)-estradiol and Tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice

Helicobacter pylori infection promotes male predominant gastric adenocarcinoma in humans. Estrogens reduce gastric cancer risk and previous studies showed that prophylactic 17β-estradiol (E2) in INS-GAS mice decreases H. pylori-induced carcinogenesis. We examined the effect of E2 and tamoxifen (TAM)...

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Main Authors: Sheh, Alexander (Contributor), Ge, Zhongming (Contributor), Parry, Nicola Maria Anne (Contributor), Muthupalani, Sureshkumar (Contributor), Rager, Julia E. (Author), Raczynski, Arkadiusz R. (Contributor), Mobley, Melissa W. (Contributor), McCabe, Amanda F. (Contributor), Fry, Rebecca C. (Author), Wang, Timothy C. (Author), Fox, James G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2012-12-12T18:30:46Z.
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