Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes

Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes

The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory to current interventions. We describe a new approach that directs ErbB recept...

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Main Authors: Jay, Steven M. (Contributor), Kurtagic, Elma (Contributor), Alvarez, Luis M. (Contributor), De Picciotto, Seymour (Contributor), Hawkins, Jessica F. (Author), Prince, Robin N. (Contributor), Guerrero, Yadir (Contributor), Treasure, Carolyn L. (Author), Lee, Richard T. (Author), Griffith, Linda G. (Author), Sanchez, Edgar (Author)
Other Authors: Massachusetts Institute of Technology. Center for Gynepathology Research (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sanchez Palacios, Edgar I. (Contributor)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology (ASBMB), 2012-12-18T20:14:10Z.
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