ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24-204), expressed and characterized from Escherichia coli, is a competitive inhibitor...

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Main Authors: Moss, Marcia L. (Author), Powell, Gary (Author), Miller, Miles Aaron (Contributor), Edwards, Lori (Author), Qi, Bin (Author), Qing-Xiang Amy, Sang (Author), De Strooper, Bart (Author), Tesseur, Ina (Author), Lichtenthaler, Stefan F. (Author), Taverna, Mara (Author), Zhong, Julia Li (Author), Dingwall, Colin (Author), Ferdous, Taheera (Author), Schlomann, Uwe (Author), Zhou, Pei (Author), Griffith, Linda G. (Contributor), Lauffenburger, Douglas A. (Contributor), Petrovich, Robert (Author), Bartsch, Jorg W. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology, 2013-01-08T16:55:29Z.
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