Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

Background: Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between senescence and DDR with macrophage levels in inflammatory bowel disease (IBD...

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Main Authors: Sohn, Jane J. (Author), Schetter, Aaron J. (Author), Yfantis, Harris G. (Author), Ridnour, Lisa A. (Author), Horikawa, Izumi (Author), Kahn, Mohammed A. (Author), Robles, Ana I. (Author), Hussain, S. Perwez (Author), Goto, Akiteru (Author), Bowman, Elise D. (Author), Hofseth, Lorne J. (Author), Bartkova, Jirina (Author), Bartek, Jiri (Author), Wogan, Gerald N. (Contributor), Wink, David A. (Author), Harris, Curtis C. (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-01-23T20:57:13Z.
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