Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production

Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production

Isoprenoids are natural products that are all derived from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). These precursors are synthesized either by the mevalonate (MVA) pathway or the 1-Deoxy-D-Xylulose 5-Phosphate (DXP) pathway. Metabolic engineering of microbes has enabled o...

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Bibliographic Details
Main Authors: Zhou, Kang (Contributor), Zou, Ruiyang (Contributor), Stephanopoulos, Gregory (Contributor), Too, Heng-Phon (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Singapore-MIT Alliance in Research and Technology (SMART) (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-01-30T15:31:44Z.
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