Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although significant progress has been made in visualizing tumor cell motility in vivo, the underlying mechanism of cancer cell intravasation remains largely unknown. We developed a microfluidic-based assay to recrea...

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Bibliographic Details
Main Authors: Zervantonakisa, Ioannis K. (Contributor), Hughes-Alford, Shannon Kay (Contributor), Charest, Joseph L. (Contributor), Condeelis, John S. (Author), Gertler, Frank (Contributor), Kamm, Roger Dale (Contributor)
Other Authors: Charles Stark Draper Laboratory (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-03-06T18:17:04Z.
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