A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC). Here, we characterize the small molecule 5-iodotuberc...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Rockefeller University Press,
2013-03-12T19:07:50Z.
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| Subjects: | |
| Online Access: | Get fulltext |