A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC). Here, we characterize the small molecule 5-iodotuberc...
Main Authors: | Santaguida, Stefano (Contributor), De Antoni, Anna (Author), Maffini, Stefano (Author), Knapp, Stefan (Author), Musacchio, Andrea (Author) |
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Other Authors: | Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
Rockefeller University Press,
2013-03-12T19:07:50Z.
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Subjects: | |
Online Access: | Get fulltext |
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