Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. The interaction of PKM2 with phosphotyrosine-containing proteins inhibits enzyme activity and incr...

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Bibliographic Details
Main Authors: Yu, Yimin (Contributor), Israelsen, William James (Contributor), Mattaini, Katherine Ruth (Contributor), Fiske, Brian Prescott (Contributor), Malstrom, Scott E. (Contributor), Khan, Tahsin M. (Contributor), Lunt, Sophia Yunkyungkwon (Contributor), Johnson, Zachary (Contributor), Davidson, Shawn Michael (Contributor), Vander Heiden, Matthew G. (Contributor), Jha, Abhishek K. (Contributor), Stephano, Gregory (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Stephanopoulos, Gregory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-03-15T18:56:26Z.
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