Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. The interaction of PKM2 with phosphotyrosine-containing proteins inhibits enzyme activity and incr...
Main Authors: | , , , , , , , , , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2013-03-15T18:56:26Z.
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Subjects: | |
Online Access: | Get fulltext |