The impact of negative selection on thymocyte migration in the medulla

The impact of negative selection on thymocyte migration in the medulla

Developing thymocytes are screened for self-reactivity before they exit the thymus, but how thymocytes scan the medulla for self antigens is unclear. Using two-photon microscopy, we observed that medullary thymocytes migrated rapidly and made frequent, transient contacts with dendritic cells. In the...

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Main Authors: Borgne, Marie Le (Author), Ladi, Ena (Author), Dzhagalov, Ivan (Author), Herzmark, Paul (Author), Liao, Ying Fang (Author), Chakraborty, Arup K. (Contributor), Robey, Ellen A. (Author)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-03-21T16:02:33Z.
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